Moderate levels of depression predict sexual transmission risk in HIV-infected MSM: A longitudinal analysis of data from six sites involved in a "prevention for positives" study

Conall O'Cleirigh, Michael E. Newcomb, Kenneth H. Mayer, Margie Skeer, Lara Traeger, Steven A. Safren

Research output: Contribution to journalArticle

47 Scopus citations


Depression is highly comorbid with HIV and may contribute to increased sexual transmission risk behavior (TRB) amongst HIV-infected MSM, the largest risk group for HIV in the U.S. However, examinations of this effect are inconsistent. The present longitudinal analyses of 746 HIV-infected MSM is from a multi-site "prevention for positives" study. A non-linear association between depression and TRB emerged. Moderate levels of depression (compared to either low or high levels) were associated with a more modest decline in the odds of sexual risk behavior over 12-month follow-up. Assessing depression in HIV primary care settings may help to identify those at risk and integrating the treatment of depression into secondary prevention and treatment initiatives may decrease the likelihood of sexual risk and help to contain the epidemic among MSM.

Original languageEnglish (US)
Pages (from-to)1764-1769
Number of pages6
JournalAIDS and Behavior
Issue number5
StatePublished - Jun 1 2013



  • Depression
  • HIV prevention with positives
  • Men who have sex with men
  • Sexual risk

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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