Models of chronic kidney disease

Hai Chun Yang, Yiqin Zuo, Agnes B. Fogo

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations


Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules, interstitium and/or vasculature. To study pathogenesis, mechanisms and effects of interventions, many animal models have been developed, including spontaneous, genetic and induced models. However, these models do not exactly simulate human diseases, and most of them are strain, gender or age dependent. We review key information on various rodent models of chronic kidney diseases.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number1-2
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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