Models and mechanisms in malignant melanoma

Cara L. Benjamin, Vladislava O. Melnikova, Honnavara N. Ananthaswamy

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Human melanoma represents the fastest growing malignancy in the US. The etiology of melanoma is highly debated as is the role of ultraviolet (UV) radiation in the initiation and progression of melanoma. This article discusses data from UV exposure and its relationship to the development of melanoma from various models of melanoma as well as various genetic alterations seen in oncogenic transformation of melanocytes. Genetic alterations such as the p16INK4a deletion, melanocortin 1 receptor (MC1R), RAS, and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) may be indicative of a predisposition to melanoma development. Historical research as well as current data on the significance of the hot spot mutation in BRAF is discussed in its relative potential to the activating mutation in RAS.

Original languageEnglish (US)
Pages (from-to)671-678
Number of pages8
JournalMolecular Carcinogenesis
Volume46
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • BRAF
  • Melanoma
  • PTEN
  • RAS
  • UV radiation

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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