Modelling the transmission dynamics of meticillin-resistant Staphylococcus aureus in Beijing Tongren hospital

J. Wang, L. Wang, P. Magal, Y. Wang, J. Zhuo, X. Lu, S. Ruan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Semi-professional volunteers work in many tertiary care hospitals in China as healthcare assistants. Proper infection control measures are needed to reduce nosocomial transmission involving volunteers. A compartmental model was constructed to describe the transmission characteristics of meticillin-resistant Staphylococcus aureus (MRSA) in the emergency ward (EW) and respiratory intensive care unit (RICU) for volunteers in Beijing Tongren Hospital, Beijing, China. The model consists of components describing uncolonized and colonized patients, uncontaminated and contaminated healthcare workers (HCWs), and uncontaminated and contaminated volunteers. The basic reproduction number (R0) was calculated, and the dependence of R0 on various model parameters was analysed. Moreover, simulations of the model were performed for comparision with the reported data on the numbers of colonized patients in the EW and RICU from 3 March 2009 to 28 February 2010, respectively. Sensitivity analysis of R0 showed that increasing handwashing compliance among HCWs and volunteers would reduce the risk of transmission dramatically. As volunteers care for patients on a one-to-one basis, this study showed that the number of MRSA-positive patients would increase if volunteers were replaced by HCWs. Therefore, in addition to improving hand hygiene among HCWs, the employment of properly trained volunteers is an attractive alternative to decrease MRSA and other multi-drug resistant bacteria infections in the hospital setting.

Original languageEnglish (US)
Pages (from-to)302-308
Number of pages7
JournalJournal of Hospital Infection
Volume79
Issue number4
DOIs
StatePublished - Dec 2011

Keywords

  • Basic reproduction number
  • Mathematical modelling
  • Meticillin-resistant Staphylococcus aureus
  • Transmission dynamics
  • Volunteers

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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