TY - JOUR
T1 - Modelling homosexual and heterosexual transmissions of hepatitis B virus in China
AU - Lu, Min
AU - Shu, Yaqin
AU - Huang, Jicai
AU - Ruan, Shigui
AU - Zhang, Xinan
AU - Zou, Lan
N1 - Funding Information:
Research was partially supported by NSFC [grant numbers 11771168, 11831012, 11871235] and the Fundamental Research Funds for the Central Universities [grant number CCNU19TS030]. The authors would like to thank the editor and anonymous reviewers for their helpful comments and suggestions which helped us to improve the manuscript.
Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Studies have shown that sexual transmission, both heterosexually and homosexually, is one of the main ways of HBV infection. Based on this fact, we propose a mathematical model to study the sexual transmission of HBV among adults by classifying adults into men and women and considering both same-sex and opposite-sex transmissions of HBV in adults. Firstly, we calculate the basic reproduction number (Formula presented.) and the disease-free equilibrium point (Formula presented.). Secondly, by analysing the sensitivity of (Formula presented.) in terms of model parameters, we find that the infection rate among people who have same-sex partners, the frequency of homosexual contact and the immunity rate of adults play important roles in the transmission of HBV. Moreover, we use our model to fit the reported data in China and forecast the trend of hepatitis B. Our results demonstrate that popularizing the basic knowledge of HBV among residents, advocating healthy and reasonable sexual life style, reducing the number of adult carriers, and increasing the immunization rate of adults are effective measures to prevent and control hepatitis B.
AB - Studies have shown that sexual transmission, both heterosexually and homosexually, is one of the main ways of HBV infection. Based on this fact, we propose a mathematical model to study the sexual transmission of HBV among adults by classifying adults into men and women and considering both same-sex and opposite-sex transmissions of HBV in adults. Firstly, we calculate the basic reproduction number (Formula presented.) and the disease-free equilibrium point (Formula presented.). Secondly, by analysing the sensitivity of (Formula presented.) in terms of model parameters, we find that the infection rate among people who have same-sex partners, the frequency of homosexual contact and the immunity rate of adults play important roles in the transmission of HBV. Moreover, we use our model to fit the reported data in China and forecast the trend of hepatitis B. Our results demonstrate that popularizing the basic knowledge of HBV among residents, advocating healthy and reasonable sexual life style, reducing the number of adult carriers, and increasing the immunization rate of adults are effective measures to prevent and control hepatitis B.
KW - basic reproduction number
KW - Hepatitis B virus
KW - heterosexual transmission
KW - homosexual transmission
KW - mathematical modelling
KW - sensitivity analysis
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U2 - 10.1080/17513758.2021.1896797
DO - 10.1080/17513758.2021.1896797
M3 - Article
C2 - 33704015
AN - SCOPUS:85102458549
VL - 15
SP - 177
EP - 194
JO - Journal of Biological Dynamics
JF - Journal of Biological Dynamics
SN - 1751-3758
IS - 1
ER -