Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases

Mostafa Adimya, Fabien Craustea, Shigui Ruanb

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed to understand some blood diseases characterized by very long period oscillations in circulating blood cells. A system of three differential equations with delay, corresponding to the cell cycle duration, is proposed and analyzed. The existence of a Hopf bifurcation at a positive steady-state is obtained through the study of an exponential polynomial characteristic equation with delay-dependent coefficients. Numerical simulations show that long-period oscillations can be obtained in this model, corresponding to a destabilization of the feedback regulation between blood cells and growth factors, for reasonable cell cycle durations. These oscillations can be related to observations on some periodic hematological diseases (such as chronic myelogenous leukemia, for example).

Original languageEnglish (US)
Pages (from-to)2321-2351
Number of pages31
JournalBulletin of Mathematical Biology
Volume68
Issue number8
DOIs
StatePublished - Nov 2006

Keywords

  • Cell population models
  • Characteristic equation
  • Delay differential equations
  • Delay-dependent coefficients
  • Hematopoiesis
  • Hopf bifurcation
  • Stability switch
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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