Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals

E. M C D'Agata, Glenn F. Webb, Mary Ann Horn, Robert C. Moellering, Shigui Ruan

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background. Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been associated with infections in hospitals. Recently, a new strain of MRSA has emerged and rapidly spread in the community, causing serious infections among young, healthy individuals. Preliminary reports imply that a particular clone (USA300) of a community-acquired MRSA (CA-MRSA) strain is infiltrating hospitals and replacing the traditional hospital-acquired MRSA strains. If true, this event would have serious consequences, because CA-MRSA infections in hospitals would occur among a more debilitated, older patient population. Methods. A deterministic mathematical model was developed to characterize the factors contributing to the replacement of hospital-acquired MRSA with CA-MRSA and to quantify the effectiveness of interventions aimed at limiting the spread of CA-MRSA in health care settings. Results. The model strongly suggests that CA-MRSA will become the dominant MRSA strain in hospitals and health care facilities. This reversal of dominant strain will occur as a result of the documented expanding community reservoir and increasing influx into the hospital of individuals who harbor CA-MRSA. Competitive exclusion of hospital-acquired MRSA by CA-MRSA will occur, with increased severity of CA-MRSA infections resulting in longer hospitalizations and a larger in-hospital reservoir of CA-MRSA. Conclusions. Improving compliance with hand hygiene and screening for and decolonization of CA-MRSA carriers are effective strategies. However, hand hygiene has the greatest return of benefits and, if compliance is optimized, other strategies may have minimal added benefit.

Original languageEnglish (US)
Pages (from-to)274-284
Number of pages11
JournalClinical Infectious Diseases
Volume48
Issue number3
DOIs
StatePublished - Feb 1 2009

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Methicillin-Resistant Staphylococcus aureus
Hand Hygiene
Community-Acquired Infections
Delivery of Health Care
Health Facilities
Cross Infection
Compliance

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. / D'Agata, E. M C; Webb, Glenn F.; Horn, Mary Ann; Moellering, Robert C.; Ruan, Shigui.

In: Clinical Infectious Diseases, Vol. 48, No. 3, 01.02.2009, p. 274-284.

Research output: Contribution to journalArticle

D'Agata, E. M C ; Webb, Glenn F. ; Horn, Mary Ann ; Moellering, Robert C. ; Ruan, Shigui. / Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. In: Clinical Infectious Diseases. 2009 ; Vol. 48, No. 3. pp. 274-284.
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