Modeling of asthma, COPD and cystic fibrosis in sheep

William M. Abraham

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Sheep naturally allergic to Ascaris suum antigen have been used to study the pathophysiology of asthma and more recently allergic rhinitis, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The utility of the model as it relates to the study of these diseases is discussed.

Original languageEnglish (US)
Pages (from-to)743-754
Number of pages12
JournalPulmonary Pharmacology and Therapeutics
Issue number5
StatePublished - Oct 1 2008


  • Airway inflammation
  • Animal models
  • Bronchoconstriction
  • Mucus clearance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology


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