Modeling large nucleic acids

Arun Malhotra; Henry A. Gabb; Stephen C. Harvey

doi:10.1016/S0959-440X(05)80159-9

Modeling large nucleic acids

Arun Malhotra, Henry A. Gabb, Stephen C. Harvey

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.

Original language	English (US)
Pages (from-to)	241-246
Number of pages	6
Journal	Current Opinion in Structural Biology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S0959-440X(05)80159-9
State	Published - Apr 1993
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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title = "Modeling large nucleic acids",

abstract = "During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.",

author = "Arun Malhotra and Gabb, {Henry A.} and Harvey, {Stephen C.}",

note = "Funding Information: by grants from the National Science Foundation and the National Institutes of Health (GM-34015).",

year = "1993",

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doi = "10.1016/S0959-440X(05)80159-9",

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AU - Harvey, Stephen C.

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AB - During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.

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DO - 10.1016/S0959-440X(05)80159-9

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