Modeling large nucleic acids

Arun Malhotra, Henry A. Gabb, Stephen C. Harvey

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

During the past year, a variety of methods have been developed with which to investigate the structures of large nucleic acids. Modeling techniques are assisting in the refinement of structures, particularly for large RNAs. Supercoiled DNA plasmids are being investigated using models that mimic the known elastic properties of the molecule. The level of detail in a particular modeling method must be appropriate to the question being posed.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume3
Issue number2
DOIs
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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