Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration

Erika M C D'Agata, Pierre Magal, Damien Olivier, Shigui Ruan, Glenn F. Webb

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. To simplify the interpretation and application of the model's conclusions, a corresponding deterministic model was created, which describes the average behavior of the IBM over a large number of simulations. The integration of these two model systems provides a quantitative analysis of the emergence and spread of antibiotic-resistant bacteria, and demonstrates that early initiation of treatment and minimization of its duration mitigates antibiotic resistance epidemics in hospitals.

Original languageEnglish (US)
Pages (from-to)487-499
Number of pages13
JournalJournal of Theoretical Biology
Volume249
Issue number3
DOIs
StatePublished - Dec 7 2007

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Antibiotics
Microbial Drug Resistance
antibiotic resistance
Anti-Bacterial Agents
Individual-based Model
duration
Modeling
Bacteria
antibiotics
Pathogens
Public Health
Deterministic Model
Quantitative Analysis
pathogens
bacteria
Infection
Public health
Medical problems
Simplify
quantitative analysis

Keywords

  • Antibiotic-resistant bacteria
  • Basic reproduction number
  • Differential equation model
  • Individual-based model

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Modeling antibiotic resistance in hospitals : The impact of minimizing treatment duration. / D'Agata, Erika M C; Magal, Pierre; Olivier, Damien; Ruan, Shigui; Webb, Glenn F.

In: Journal of Theoretical Biology, Vol. 249, No. 3, 07.12.2007, p. 487-499.

Research output: Contribution to journalArticle

D'Agata, Erika M C ; Magal, Pierre ; Olivier, Damien ; Ruan, Shigui ; Webb, Glenn F. / Modeling antibiotic resistance in hospitals : The impact of minimizing treatment duration. In: Journal of Theoretical Biology. 2007 ; Vol. 249, No. 3. pp. 487-499.
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