Abstract
In this paper, we develop a mathematical model to study the transmission dynamics of visceral leishmaniasis. Three populations: dogs, sandies and humans, are considered in the model. Based on recent studies, we include vertical transmission of dogs in the spread of the disease. We also investigate the impact of asymptomatic humans and dogs as secondary reservoirs of the parasites. The basic reproduction number and sensitivity analysis show that the control of dog-sandy transmission is more important for the elimination of the disease. Vaccination of susceptible dogs, treatment of infective dogs, as well as control of vertical transmission in dogs are effective prevention and control measures for visceral leishmaniasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1585-1604 |
| Number of pages | 20 |
| Journal | Mathematical Biosciences and Engineering |
| Volume | 14 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - Oct 1 2017 |
Keywords
- Basic reproduction number
- Mathematical modeling
- Reservoir
- Vertical transmission
- Visceral leishmaniasis
ASJC Scopus subject areas
- Modeling and Simulation
- Agricultural and Biological Sciences(all)
- Computational Mathematics
- Applied Mathematics
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Cite this
Zou, L., Chen, J., & Ruan, S. (2017). Modeling and analyzing the transmission dynamics of visceral leishmaniasis. Mathematical Biosciences and Engineering, 14(5-6), 1585-1604. https://doi.org/10.3934/mbe.2017082