Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women

Elizabeth G. Livingston, Yanling Huo, Kunjal Patel, Susan B. Brogly, Ruth Tuomala, Gwendolyn B Scott, Arlene Bardeguez, Alice Stek, Jennifer S. Read

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To estimate risk of infant respiratory morbidity associated with cesarean delivery before labor and ruptured membranes among HIV-1-infected women. Methods: In a prospective cohort study of HIV-1-infected women and their infants, mode of delivery was determined by clinicians at the participating sites. For this analysis, "elective cesarean delivery" was defined as any cesarean delivery, regardless of gestational age, without labor and with duration of ruptured membranes of less than 5 minutes. Nonelective cesarean deliveries were those performed after the onset of labor, rupture of membranes, or both. Vaginal delivery included normal spontaneous and instrument deliveries. Associations between mode of delivery and infant respiratory morbidity were assessed using χ or Fisher's exact test. Adjusted odds of respiratory distress syndrome by delivery mode were assessed using multivariable logistic regression. Results: Among 1,194 mother-infant pairs, there were significant differences according to mode of delivery in median gestational age (weeks) at delivery (vaginal, n=566, median=38.8; nonelective cesarean, n=216, median=38.0; and elective cesarean, n=412, median 38.1; P<.001) and incidence of respiratory distress syndrome (vaginal, n=9, 1.6%, reference; nonelective cesarean, n=16, 7.4%; elective cesarean, n=18; 4.4%; (P<.001). In analyses adjusted for gestational age and birth weight, mode of delivery was not statistically significantly associated with infant respiratory distress syndrome (P=.10), although a trend toward an increased risk of respiratory distress syndrome among infants delivered by cesarean was suggested (nonelective cesarean adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 0.95-5.67; elective cesarean OR 2.56, 95% CI 1.01-6.48). Conclusion: Respiratory distress syndrome rates associated with elective cesarean delivery among HIV-1-infected women are low, comparable with published rates among uninfected women. There is minimal neonatal respiratory morbidity risk in near-term infants born by elective cesarean delivery to HIV-1-infected women.

Original languageEnglish
Pages (from-to)335-343
Number of pages9
JournalObstetrics and Gynecology
Volume116
Issue number2 PART 1
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

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HIV-1
Morbidity
Gestational Age
Newborn Respiratory Distress Syndrome
Membranes
Odds Ratio
Confidence Intervals
Labor Onset
Birth Weight
Rupture
Cohort Studies
Logistic Models
Mothers
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Livingston, E. G., Huo, Y., Patel, K., Brogly, S. B., Tuomala, R., Scott, G. B., ... Read, J. S. (2010). Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women. Obstetrics and Gynecology, 116(2 PART 1), 335-343. https://doi.org/10.1097/AOG.0b013e3181e8f38a

Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women. / Livingston, Elizabeth G.; Huo, Yanling; Patel, Kunjal; Brogly, Susan B.; Tuomala, Ruth; Scott, Gwendolyn B; Bardeguez, Arlene; Stek, Alice; Read, Jennifer S.

In: Obstetrics and Gynecology, Vol. 116, No. 2 PART 1, 01.08.2010, p. 335-343.

Research output: Contribution to journalArticle

Livingston, EG, Huo, Y, Patel, K, Brogly, SB, Tuomala, R, Scott, GB, Bardeguez, A, Stek, A & Read, JS 2010, 'Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women', Obstetrics and Gynecology, vol. 116, no. 2 PART 1, pp. 335-343. https://doi.org/10.1097/AOG.0b013e3181e8f38a
Livingston, Elizabeth G. ; Huo, Yanling ; Patel, Kunjal ; Brogly, Susan B. ; Tuomala, Ruth ; Scott, Gwendolyn B ; Bardeguez, Arlene ; Stek, Alice ; Read, Jennifer S. / Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 2 PART 1. pp. 335-343.
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abstract = "Objective: To estimate risk of infant respiratory morbidity associated with cesarean delivery before labor and ruptured membranes among HIV-1-infected women. Methods: In a prospective cohort study of HIV-1-infected women and their infants, mode of delivery was determined by clinicians at the participating sites. For this analysis, {"}elective cesarean delivery{"} was defined as any cesarean delivery, regardless of gestational age, without labor and with duration of ruptured membranes of less than 5 minutes. Nonelective cesarean deliveries were those performed after the onset of labor, rupture of membranes, or both. Vaginal delivery included normal spontaneous and instrument deliveries. Associations between mode of delivery and infant respiratory morbidity were assessed using χ or Fisher's exact test. Adjusted odds of respiratory distress syndrome by delivery mode were assessed using multivariable logistic regression. Results: Among 1,194 mother-infant pairs, there were significant differences according to mode of delivery in median gestational age (weeks) at delivery (vaginal, n=566, median=38.8; nonelective cesarean, n=216, median=38.0; and elective cesarean, n=412, median 38.1; P<.001) and incidence of respiratory distress syndrome (vaginal, n=9, 1.6{\%}, reference; nonelective cesarean, n=16, 7.4{\%}; elective cesarean, n=18; 4.4{\%}; (P<.001). In analyses adjusted for gestational age and birth weight, mode of delivery was not statistically significantly associated with infant respiratory distress syndrome (P=.10), although a trend toward an increased risk of respiratory distress syndrome among infants delivered by cesarean was suggested (nonelective cesarean adjusted odds ratio [OR] 2.32, 95{\%} confidence interval [CI] 0.95-5.67; elective cesarean OR 2.56, 95{\%} CI 1.01-6.48). Conclusion: Respiratory distress syndrome rates associated with elective cesarean delivery among HIV-1-infected women are low, comparable with published rates among uninfected women. There is minimal neonatal respiratory morbidity risk in near-term infants born by elective cesarean delivery to HIV-1-infected women.",
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AU - Huo, Yanling

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AU - Tuomala, Ruth

AU - Scott, Gwendolyn B

AU - Bardeguez, Arlene

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AU - Read, Jennifer S.

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N2 - Objective: To estimate risk of infant respiratory morbidity associated with cesarean delivery before labor and ruptured membranes among HIV-1-infected women. Methods: In a prospective cohort study of HIV-1-infected women and their infants, mode of delivery was determined by clinicians at the participating sites. For this analysis, "elective cesarean delivery" was defined as any cesarean delivery, regardless of gestational age, without labor and with duration of ruptured membranes of less than 5 minutes. Nonelective cesarean deliveries were those performed after the onset of labor, rupture of membranes, or both. Vaginal delivery included normal spontaneous and instrument deliveries. Associations between mode of delivery and infant respiratory morbidity were assessed using χ or Fisher's exact test. Adjusted odds of respiratory distress syndrome by delivery mode were assessed using multivariable logistic regression. Results: Among 1,194 mother-infant pairs, there were significant differences according to mode of delivery in median gestational age (weeks) at delivery (vaginal, n=566, median=38.8; nonelective cesarean, n=216, median=38.0; and elective cesarean, n=412, median 38.1; P<.001) and incidence of respiratory distress syndrome (vaginal, n=9, 1.6%, reference; nonelective cesarean, n=16, 7.4%; elective cesarean, n=18; 4.4%; (P<.001). In analyses adjusted for gestational age and birth weight, mode of delivery was not statistically significantly associated with infant respiratory distress syndrome (P=.10), although a trend toward an increased risk of respiratory distress syndrome among infants delivered by cesarean was suggested (nonelective cesarean adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 0.95-5.67; elective cesarean OR 2.56, 95% CI 1.01-6.48). Conclusion: Respiratory distress syndrome rates associated with elective cesarean delivery among HIV-1-infected women are low, comparable with published rates among uninfected women. There is minimal neonatal respiratory morbidity risk in near-term infants born by elective cesarean delivery to HIV-1-infected women.

AB - Objective: To estimate risk of infant respiratory morbidity associated with cesarean delivery before labor and ruptured membranes among HIV-1-infected women. Methods: In a prospective cohort study of HIV-1-infected women and their infants, mode of delivery was determined by clinicians at the participating sites. For this analysis, "elective cesarean delivery" was defined as any cesarean delivery, regardless of gestational age, without labor and with duration of ruptured membranes of less than 5 minutes. Nonelective cesarean deliveries were those performed after the onset of labor, rupture of membranes, or both. Vaginal delivery included normal spontaneous and instrument deliveries. Associations between mode of delivery and infant respiratory morbidity were assessed using χ or Fisher's exact test. Adjusted odds of respiratory distress syndrome by delivery mode were assessed using multivariable logistic regression. Results: Among 1,194 mother-infant pairs, there were significant differences according to mode of delivery in median gestational age (weeks) at delivery (vaginal, n=566, median=38.8; nonelective cesarean, n=216, median=38.0; and elective cesarean, n=412, median 38.1; P<.001) and incidence of respiratory distress syndrome (vaginal, n=9, 1.6%, reference; nonelective cesarean, n=16, 7.4%; elective cesarean, n=18; 4.4%; (P<.001). In analyses adjusted for gestational age and birth weight, mode of delivery was not statistically significantly associated with infant respiratory distress syndrome (P=.10), although a trend toward an increased risk of respiratory distress syndrome among infants delivered by cesarean was suggested (nonelective cesarean adjusted odds ratio [OR] 2.32, 95% confidence interval [CI] 0.95-5.67; elective cesarean OR 2.56, 95% CI 1.01-6.48). Conclusion: Respiratory distress syndrome rates associated with elective cesarean delivery among HIV-1-infected women are low, comparable with published rates among uninfected women. There is minimal neonatal respiratory morbidity risk in near-term infants born by elective cesarean delivery to HIV-1-infected women.

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