Modal gating of NMDA receptors

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations


The decay time course of excitatory postsynaptic currents generated by slow glutamatergic synapses is determined by the single-channel kinetics of postsynaptic NMDA receptor channels. In a recent study, examination of these single-channel kinetics has revealed that NMDA receptors can enter into modal gating. Linear free-energy analysis suggests that the various modes arise from a common reaction mechanism, providing further insight into the gating underlying decay of the slow synaptic response.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalTrends in Neurosciences
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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