Modafinil for the treatment of pain-associated fatigue: Review and case report

David A. Fishbain, R. B. Cutler, J. Lewis, B. Cole, H. L. Rosomoff, R. Steele-Rosomoff

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Fatigue is a symptom that is frequently found in chronic pain patients with low back pain and/or neck pain. At the present time, no specific psychopharmacological treatment for this problem has been identified. Modafinil is a wakefulness-promoting agent that the FDA has approved for the treatment of excessive daytime sleepiness associated with narcolepsy. There have been reports on the use of modafinil for the treatment of fatigue in various neurological syndromes. This literature is reviewed. As such, modafinil treatment was initiated for a patient with severe fatigue associated with chronic low back pain and neck pain. There was dramatic improvement in fatigue and associated function. This case is described. It is the first such case report in the literature. The significance of this finding to the treatment of pain-associated fatigue is discussed.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalJournal of Pain and Palliative Care Pharmacotherapy
Issue number2
StatePublished - Jan 1 2004


  • Case report
  • Fatigue
  • Modafinil
  • Pain
  • Review

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Anesthesiology and Pain Medicine
  • Pharmacology (medical)


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