Mixed intestinal adenocarcinoma-argentaffin carcinoma of the vagina

Michio Fukushima, Leo B. Twiggs, Takashi Okagaki

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A mixed intestinal adenocarcinoma-argentaffin carcinoma of the vagina in a 32-year-old woman is reported. Special stains showed the argentaffln and argyrophil reactions of the small cell population of this tumor. The small cells also contained serotonin as demonstrated by immunocytochemistry. Electron microscopy revealed characteristic cytoplasmic neurosecretory granules. The large cells were columnar and contained mucin droplets similar to those in Goblet cells in the intestines. The observations suggest that the tumor was mixed intestinal adenocarcinoma-argentaffin carcinoma (malignant carcinoid), which probably arose in aberrant intestinal epithelial cells in the vagina. The patient died with metastases of pure argentaffln carcinoma in 1 year.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalGynecologic oncology
Issue number3
StatePublished - Mar 1986

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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