Mitral regurgitation

Robert V. Kelly, Mauricio G. Cohen, George A. Stouffer

Research output: Chapter in Book/Report/Conference proceedingChapter


The natural history of chronic mitral regurgitation (MR) is variable and depends on the regurgitant volume, left ventricular (LV) function, and the underlying cause of MR. The development of symptoms at rest in chronic MR can be an ominous finding, especially if coupled with decrease in left ventricular (LV) systolic function. MR can be caused by structural abnormalities of the mitral leaflets, papillary muscles, chordae tendineae, or mitral annulus. Acute MR is a rare but potentially life-threatening condition that is generally associated with abrupt onset of dyspnea, heart failure, and shock. LV end-systolic volume (LVESV) is an important pre-operative prognostic marker, especially in terms of mortality, post-operative heart failure, and post-operative LV systolic function. The mitral valve, valve apparatus, chordae, and papillary muscles can be visualized on echocardiography. Reversal of Doppler flow in pulmonary veins during systole can also be assessed and is an important indicator of severe MR.

Original languageEnglish (US)
Title of host publicationCardiovascular Hemodynamics for the Clinician
Subtitle of host publicationSecond Edition
Number of pages9
ISBN (Electronic)9781119066491
ISBN (Print)9781119066477
StatePublished - Oct 4 2016


  • Cardiac catheterization
  • Chronic mitral regurgitation
  • Doppler flow
  • Echocardiography
  • Heart failure
  • LV end-systolic volume
  • Left ventricular systolic function
  • Post-operative LV systolic function

ASJC Scopus subject areas

  • Medicine(all)


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