Mitogenic regulation of normal and malignant breast epithelium

Marc E Lippman, R. B. Dickson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The multiple roles of both estrogenic and polypeptide regulators of mammary epithelial cell growth are reviewed in this article. Effects of both steroidal and peptide hormones are complex and involve multiple interactions with malignant cells and non-malignant host components. Initial carcinogenesis and progression of mammary epithelium to cancer probably require both proliferative stimuli (estrogen, polypeptide growth factors) and genetic damage. This condition may lead to qualitatively different hormonal responses (hormone-responsive cancer). Estrogens can be shown to induce growth-regulatory polypeptide growth factors and interact with them in hormone-dependent breast cancer. Progression of hormone-dependent (estrogen-responsive) breast cancer to hormone independence probably involves multiple mechanisms, including oncogene activation, loss of the estrogen receptor, or loss of hormone responsivity of other gene products. One direction for further therapies may be blockade of hormonal stimulation and interference with necessary activated or induced components of malignant progression such as oncogenes or polypeptide growth factor-receptor systems.

Original languageEnglish
Pages (from-to)459-480
Number of pages22
JournalYale Journal of Biology and Medicine
Volume62
Issue number5
StatePublished - Dec 1 1989
Externally publishedYes

Fingerprint

Breast
Epithelium
Hormones
Peptides
Estrogens
Oncogenes
Intercellular Signaling Peptides and Proteins
Breast Neoplasms
Growth Factor Receptors
Peptide Hormones
Cell growth
Growth
Estrogen Receptors
Neoplasms
Carcinogenesis
Genes
Epithelial Cells
Chemical activation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mitogenic regulation of normal and malignant breast epithelium. / Lippman, Marc E; Dickson, R. B.

In: Yale Journal of Biology and Medicine, Vol. 62, No. 5, 01.12.1989, p. 459-480.

Research output: Contribution to journalArticle

Lippman, ME & Dickson, RB 1989, 'Mitogenic regulation of normal and malignant breast epithelium', Yale Journal of Biology and Medicine, vol. 62, no. 5, pp. 459-480.
Lippman, Marc E ; Dickson, R. B. / Mitogenic regulation of normal and malignant breast epithelium. In: Yale Journal of Biology and Medicine. 1989 ; Vol. 62, No. 5. pp. 459-480.
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