Mitogenic regulation of normal and malignant breast epithelium

M. E. Lippman, R. B. Dickson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The multiple roles of both estrogenic and polypeptide regulators of mammary epithelial cell growth are reviewed in this article. Effects of both steroidal and peptide hormones are complex and involve multiple interactions with malignant cells and non-malignant host components. Initial carcinogenesis and progression of mammary epithelium to cancer probably require both proliferative stimuli (estrogen, polypeptide growth factors) and genetic damage. This condition may lead to qualitatively different hormonal responses (hormone-responsive cancer). Estrogens can be shown to induce growth-regulatory polypeptide growth factors and interact with them in hormone-dependent breast cancer. Progression of hormone-dependent (estrogen-responsive) breast cancer to hormone independence probably involves multiple mechanisms, including oncogene activation, loss of the estrogen receptor, or loss of hormone responsivity of other gene products. One direction for further therapies may be blockade of hormonal stimulation and interference with necessary activated or induced components of malignant progression such as oncogenes or polypeptide growth factor-receptor systems.

Original languageEnglish (US)
Pages (from-to)459-480
Number of pages22
JournalYale Journal of Biology and Medicine
Volume62
Issue number5
StatePublished - Dec 1 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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