Mitochondrion: A promising target for nanoparticle-based vaccine delivery systems

Ru Wen, Afoma C. Umeano, Lily Francis, Nivita Sharma, Smanla Tundup, Shanta Dhar

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease.

Original languageEnglish (US)
Article number18
JournalVaccines
Volume4
Issue number2
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Keywords

  • Antigen delivery
  • Mitochondria targeting
  • Nanoparticles
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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