Mitochondrial ribosomes in cancer

Hyun Jung Kim, Priyanka Maiti, Antonio Barrientos

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestige of their original genome (mtDNA), and its corresponding full gene expression machinery. Proteins encoded in the mtDNA, all components of the multimeric OXPHOS enzymes, are synthesized in specialized mitochondrial ribosomes (mitoribosomes). Mitoribosomes are therefore essential in the regulation of cellular respiration. Additionally, an increasing body of literature has been reporting an alternative role for several mitochondrial ribosomal proteins as apoptosis-inducing factors. No surprisingly, the expression of genes encoding for mitoribosomal proteins, mitoribosome assembly factors and mitochondrial translation factors is modified in numerous cancers, a trait that has been linked to tumorigenesis and metastasis. In this article, we will review the current knowledge regarding the dual function of mitoribosome components in protein synthesis and apoptosis and their association with cancer susceptibility and development. We will also highlight recent developments in targeting mitochondrial ribosomes for the treatment of cancer.

Original languageEnglish (US)
JournalSeminars in Cancer Biology
DOIs
StateAccepted/In press - Jan 2 2017

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Oxidative Phosphorylation
Neoplasms
Mitochondrial DNA
Mitochondria
Apoptosis Inducing Factor
Apoptosis
Cell Respiration
Gene Expression
Proteins
Ribosomal Proteins
Mitochondrial Proteins
Eukaryotic Cells
Carcinogenesis
Mitochondrial Ribosomes
Genome
Neoplasm Metastasis
Enzymes

Keywords

  • Apoptosis
  • Cancer
  • Mitochondrial ribosomes
  • Therapy

ASJC Scopus subject areas

  • Cancer Research

Cite this

Mitochondrial ribosomes in cancer. / Kim, Hyun Jung; Maiti, Priyanka; Barrientos, Antonio.

In: Seminars in Cancer Biology, 02.01.2017.

Research output: Contribution to journalArticle

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