Mitochondrial neuroprotection in traumatic brain injury: Rationale and therapeutic strategies

Shoji Yokobori, Anna T. Mazzeo, Shyam Gajavelli, Malcolm R. Bullock

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Traumatic brain injury (TBI) is still the worldwide, leading cause of mortality and morbidity in young adults. The prognosis of TBI patients is strongly affected by secondary brain damage including mitochondrial dysfunctions. In many basic and clinical studies, mitochondrial dysfunctions, including the opening of mitochondrial permeability transition (mPT) pore, and treatments including cyclosporine A (CsA) have been studied. These evidences suggest an important role for mitochondria as therapeutic targets for neuroprotection after TBI. This review summarizes the data about normal and pathological mitochondrial function after TBI, TBI pathobiology relating to mitochondrial dysfunction and therapeutic strategies including drug treatment. This review also mentioned about glucose, lactate, and pyruvate metabolisms in TBI, including the astrocyte-neuron lactate shuttle (ANLS) hypothesis. Mitochondrial pathophysiology in TBI is still unclear. Thus, the pharmacological treatment in TBI patient is still challenging. This review could help further understanding of this topic. Hopefully, this could help further development and innovation for drug therapies in TBI.

Original languageEnglish (US)
Pages (from-to)606-619
Number of pages14
JournalCNS and Neurological Disorders - Drug Targets
Volume13
Issue number4
DOIs
StatePublished - Jan 1 2014

Keywords

  • Apoptosis
  • Astrocyte-neuron lactate shuttle
  • Cyclosporine A
  • Mitochondrial dysfunction
  • Mitochondrial permeability transition pore
  • Secondary brain injury
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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