Mitochondrial encephalomyopathies

S. DiMauro, E. Bonilla, A. Lombes, S. Shanske, C. Minetti, C. T. Moraes

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

The mitochondrial diseases present with great heterogeneity. They are often multisystemic and vary considerably in age at onset, distribution of weakness, severity, and course. Only nonthyroidal hypermetabolism has a distinctive clinical presentation. Therefore, attempts at classification have generated some controversy. This article discusses the general classification that takes into account genetic and biochemical features, which has resulted from the fast pace of biochemical and molecular genetic investigations.

Original languageEnglish (US)
Pages (from-to)483-506
Number of pages24
JournalNeurologic Clinics
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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    DiMauro, S., Bonilla, E., Lombes, A., Shanske, S., Minetti, C., & Moraes, C. T. (1990). Mitochondrial encephalomyopathies. Neurologic Clinics, 8(3), 483-506. https://doi.org/10.1016/s0733-8619(18)30332-3