Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanchan Vats, Kanta Pravalika, Madhuri Wanve, Kiran Kalia, Anupom Borah, Akhilesh Kumar, Xin Wang, Dileep R. Yavagal, Kunjan R. Dave, Pallab Bhattacharya

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.

Original languageEnglish (US)
Pages (from-to)121-136
Number of pages16
JournalTranslational stroke research
Volume10
Issue number2
DOIs
StatePublished - Apr 15 2019

Keywords

  • Cell fusion
  • Extracellular vesicles
  • Mitochondria
  • Neuroprotection
  • Reactive oxygen species
  • Stroke
  • Tunnelling nanotubes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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    Sarmah, D., Kaur, H., Saraf, J., Vats, K., Pravalika, K., Wanve, M., Kalia, K., Borah, A., Kumar, A., Wang, X., Yavagal, D. R., Dave, K. R., & Bhattacharya, P. (2019). Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Translational stroke research, 10(2), 121-136. https://doi.org/10.1007/s12975-018-0642-y