Mitochondrial DNA transcription regulation and nucleoid organization

Adriana P. Rebelo, Lloye M. Dillon, Carlos T. Moraes

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Mitochondrial biogenesis is a complex process depending on both nuclear and mitochondrial DNA (mtDNA) transcription regulation to tightly coordinate mitochondrial levels and the cell's energy demand. The energy requirements for a cell to support its metabolic function can change in response to varying physiological conditions, such as, proliferation and differentiation. Therefore, mitochondrial transcription regulation is constantly being modulated in order to establish efficient mitochondrial oxidative metabolism and proper cellular function. The aim of this article is to review the function of major protein factors that are directly involved in the process of mtDNA transcription regulation, as well as, the importance of mitochondrial nucleoid structure and its influence on mtDNA segregation and transcription regulation. Here, we discuss the current knowledge on the molecular mode of action of transcription factors comprising the mitochondrial transcriptional machinery, as well as the action of nuclear receptors on regulatory regions of the mtDNA.

Original languageEnglish (US)
Pages (from-to)941-951
Number of pages11
JournalJournal of Inherited Metabolic Disease
Volume34
Issue number4
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Mitochondrial DNA transcription regulation and nucleoid organization'. Together they form a unique fingerprint.

  • Cite this