Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning

Òscar Miró, Jordi Casademont, Antonio Barrientos, Álvaro Urbano-Márquez, Francesc Cardellach

Research output: Contribution to journalArticle

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Abstract

Clinical symptoms of acute carbon monoxide (CO) poisoning are mainly related to the capability of haemoglobin to bind CO. However, the persistence of some clinical alterations after carboxyhaemoglobin normalization suggests that other heme containing proteins, like cytochrome c oxidase, could play a role in its pathogenesis. We studied mitochondrial enzyme activities of lymphocytes from three patients suffering from acute CO poisoning. HbCO levels were 11.6%, 19.6% and 22.3% in the acute phase, 2.3%, 2.4% and 1.5% on day 3 after admission, and 1.2%, 3.3% and 1.1% on day 12. Complex II, III and glycerol-3-phosphate dehydrogenase activities remained normal along the study, while cytochrome c oxidase (complex IV) activity showed a 76% inhibition compared to controls during acute poisoning (P<0.01) and 48% at day 3 (P<0.05). The activity was normal already on day 12 after the complete disappearance of symptomatology. Our results suggest that mitochondrial cytochrome c oxidase is also a target site in human acute CO poisoning, and its extended and generalized inhibition could explain the persistence of different symptoms after the normalization of HbCO levels.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalPharmacology and Toxicology
Volume82
Issue number4
StatePublished - May 6 1998
Externally publishedYes

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Carbon Monoxide Poisoning
Electron Transport Complex IV
Carbon Monoxide
Carboxyhemoglobin
Glycerolphosphate Dehydrogenase
Heme
Poisoning
Lymphocytes
Enzyme activity
Hemoglobins
Enzymes
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Miró, Ò., Casademont, J., Barrientos, A., Urbano-Márquez, Á., & Cardellach, F. (1998). Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning. Pharmacology and Toxicology, 82(4), 199-202.

Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning. / Miró, Òscar; Casademont, Jordi; Barrientos, Antonio; Urbano-Márquez, Álvaro; Cardellach, Francesc.

In: Pharmacology and Toxicology, Vol. 82, No. 4, 06.05.1998, p. 199-202.

Research output: Contribution to journalArticle

Miró, Ò, Casademont, J, Barrientos, A, Urbano-Márquez, Á & Cardellach, F 1998, 'Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning', Pharmacology and Toxicology, vol. 82, no. 4, pp. 199-202.
Miró Ò, Casademont J, Barrientos A, Urbano-Márquez Á, Cardellach F. Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning. Pharmacology and Toxicology. 1998 May 6;82(4):199-202.
Miró, Òscar ; Casademont, Jordi ; Barrientos, Antonio ; Urbano-Márquez, Álvaro ; Cardellach, Francesc. / Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning. In: Pharmacology and Toxicology. 1998 ; Vol. 82, No. 4. pp. 199-202.
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