Mitochondrial biogenesis and turnover

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover. The mechanisms associated with these events have been intensively studied in the last 20 years and our understanding of their details is much improved. Mitochondrial biogenesis requires the participation of calcium signaling that activates a series of calcium-dependent protein kinases that in turn activate transcription factors and coactivators such as PGC-1α that regulates the expression of genes coding for mitochondrial components. In addition, mitochondrial biogenesis involves the balance of mitochondrial fission-fusion. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly play an important part in aging.

Original languageEnglish
Pages (from-to)24-35
Number of pages12
JournalCell Calcium
Volume44
Issue number1
DOIs
StatePublished - Jul 1 2008

Fingerprint

Mitochondrial Turnover
Organelle Biogenesis
Mitochondrial Genes
Mitochondrial Dynamics
Calcium Signaling
Cell Nucleus Active Transport
Organelles
Transcription Factors
Gene Expression

Keywords

  • Biogenesis
  • Mitochondria
  • PGC-1
  • Replication
  • Transcription
  • Turnover

ASJC Scopus subject areas

  • Cell Biology
  • Endocrinology

Cite this

Mitochondrial biogenesis and turnover. / Diaz, Francisca; Moraes, Carlos T.

In: Cell Calcium, Vol. 44, No. 1, 01.07.2008, p. 24-35.

Research output: Contribution to journalArticle

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