Mitochondrial biogenesis and turnover

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover. The mechanisms associated with these events have been intensively studied in the last 20 years and our understanding of their details is much improved. Mitochondrial biogenesis requires the participation of calcium signaling that activates a series of calcium-dependent protein kinases that in turn activate transcription factors and coactivators such as PGC-1α that regulates the expression of genes coding for mitochondrial components. In addition, mitochondrial biogenesis involves the balance of mitochondrial fission-fusion. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly play an important part in aging.

Original languageEnglish (US)
Pages (from-to)24-35
Number of pages12
JournalCell Calcium
Volume44
Issue number1
DOIs
StatePublished - Jul 2008

Keywords

  • Biogenesis
  • Mitochondria
  • PGC-1
  • Replication
  • Transcription
  • Turnover

ASJC Scopus subject areas

  • Cell Biology
  • Endocrinology

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