Mitochondrial alterations during carcinogenesis. A review of metabolic transformation and targets for anticancer treatments

Xiao Wang, Susana Peralta, Carlos T Moraes

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Mitochondria play important roles in multiple cellular processes including energy metabolism, cell death, and aging. Regulated energy production and utilization are critical in maintaining energy homeostasis in normal cells and functional organs. However, mitochondria go through a series of morphological and functional alterations during carcinogenesis. The metabolic profile in transformed cells is altered to accommodate their fast proliferation, confer resistance to cell death, or facilitate metastasis. These transformations also provide targets for anticancer treatment at different levels. In this review, we discuss the major modifications in cell metabolism during carcinogenesis, including energy metabolism, apoptotic and autophagic cell death, adaptation of tumor microenvironment, and metastasis. We also summarize some of the main metabolic targets for treatments.

Original languageEnglish
Pages (from-to)127-160
Number of pages34
JournalAdvances in Cancer Research
Volume119
DOIs
StatePublished - Jul 26 2013

Keywords

  • HIF1
  • Hypoxia
  • Microenvironment
  • Mitochondria
  • MtDNA
  • Respiration
  • ROS
  • Warburg

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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