Minnelide reduces tumor burden in preclinical models of osteosarcoma

Sulagna Banerjee, Venugopal Thayanithy, Veena Sangwan, Tiffany N. Mackenzie, Ashok K. Saluja, Subbaya Subramanian

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Osteosarcoma is the most common bone cancer in children and adolescents with a 5-year survival rate of about 70%. In this study, we have evaluated the preclinical therapeutic efficacy of the novel synthetic drug, Minnelide, a prodrug of triptolide on osteosarcoma. Triptolide was effective in significantly inducing apoptosis in all osteosarcoma cell lines tested but had no significant effect on the human osteoblast cells. Notably, Minnelide treatment significantly reduced tumor burden and lung metastasis in the orthotopic and lung colonization models. Triptolide/Minnelide effectively downregulated the levels of pro-survival proteins such as heat shock proteins, cMYC, survivin and targets the NF-κB pathway.

Original languageEnglish (US)
Pages (from-to)412-420
Number of pages9
JournalCancer letters
Volume335
Issue number2
DOIs
StatePublished - Jul 28 2013
Externally publishedYes

Keywords

  • Heat shock proteins
  • Minnelide
  • NF-κB
  • Osteosarcoma
  • Triptolide

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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