Minimum information about a spinal cord injury experiment: A proposed reporting standard for spinal cord injury experiments

Vance P. Lemmon, Adam R. Ferguson, Phillip G. Popovich, Xiao Ming Xu, Diane M. Snow, Michihiro Igarashi, Christine E. Beattie, John L. Bixby

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The lack of reproducibility in many areas of experimental science has a number of causes, including a lack of transparency and precision in the description of experimental approaches. This has far-reaching consequences, including wasted resources and slowing of progress. Additionally, the large number of laboratories around the world publishing articles on a given topic make it difficult, if not impossible, for individual researchers to read all of the relevant literature. Consequently, centralized databases are needed to facilitate the generation of new hypotheses for testing. One strategy to improve transparency in experimental description, and to allow the development of frameworks for computer-readable knowledge repositories, is the adoption of uniform reporting standards, such as common data elements (data elements used in multiple clinical studies) and minimum information standards. This article describes a minimum information standard for spinal cord injury (SCI) experiments, its major elements, and the approaches used to develop it. Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.

Original languageEnglish (US)
Pages (from-to)1354-1361
Number of pages8
JournalJournal of neurotrauma
Volume31
Issue number15
DOIs
StatePublished - Aug 1 2014

Keywords

  • axonal injury
  • axonal regeneration
  • MIASCI
  • spinal cord injury

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Minimum information about a spinal cord injury experiment: A proposed reporting standard for spinal cord injury experiments'. Together they form a unique fingerprint.

  • Cite this