Minimizing contrast agent dose during intraarterial gadolinium-enhanced MR angiography: In vitro assessment

Ken Pin Hwang, Jordin D. Green, Debiao Li, Orlando P. Simonetti, Scott A. Resnick, J. Paul Finn, Jeffrey L. Duerk, Reed A. Omary

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Purpose: To minimize contrast agent dosage for intra-arterial (IA) contrast-enhanced magnetic resonance angiography (CE-MRA) by examining the effects of encoding order (elliptical vs. sequential) and injection duration (100% to 30% of the acquisition time). Materials and Methods: Catheter-based IA gadolinium (Gd) injections were performed in an arterial flow phantom. Blood flow rates, injection rates, and injection durations were systematically varied. Signal-to-noise (SNR) measurements were obtained in the aorta, renal artery, and common iliac artery. Results: No significant SNR losses were observed for any of the vessels with 75% injection duration, or for the aorta and iliac artery with 50% injection duration. Excellent images of all vessels were obtained at 50% injection duration. There was no significant SNR difference between encoding schemes. Conclusion: Contrast agent dosage can be substantially reduced without loss of SNR by limiting injection to part of the imaging acquisition time.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number1
StatePublished - 2002
Externally publishedYes


  • Gadolinium (Gd)
  • Magnetic resonance (MR), contrast enhancement
  • Magnetic resonance (MR), guidance
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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