Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth

Olivera Stojadinovic, Linsey E. Lindley, Ivan Jozic, Marjana Tomic-Canic

Research output: Contribution to journalComment/debate

4 Scopus citations

Abstract

Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor. In light of this, one can speculate that some of the GC-mediated side effects can be remedied by blocking activation of the mineralocorticoid receptor. Indeed, according to Nguyen et al., local inhibition of the mineralocorticoid receptor via antagonists (spironolactone, canrenoate, and eplerenone) rescues GC-induced delayed epithelialization and accelerates wound closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte proliferation. These findings suggest that the use of mineralocorticoid receptor antagonists coupled with GC therapy may be beneficial in overcoming at least some of the GC-mediated side effects.

Original languageEnglish (US)
Pages (from-to)1938-1941
Number of pages4
JournalJournal of Investigative Dermatology
Volume136
Issue number10
DOIs
StatePublished - Oct 1 2016

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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