Abstract
Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor. In light of this, one can speculate that some of the GC-mediated side effects can be remedied by blocking activation of the mineralocorticoid receptor. Indeed, according to Nguyen et al., local inhibition of the mineralocorticoid receptor via antagonists (spironolactone, canrenoate, and eplerenone) rescues GC-induced delayed epithelialization and accelerates wound closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte proliferation. These findings suggest that the use of mineralocorticoid receptor antagonists coupled with GC therapy may be beneficial in overcoming at least some of the GC-mediated side effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1938-1941 |
| Number of pages | 4 |
| Journal | Journal of Investigative Dermatology |
| Volume | 136 |
| Issue number | 10 |
| DOIs |
|
| State | Published - Oct 1 2016 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth. / Stojadinovic, Olivera; Lindley, Linsey E.; Jozic, Ivan; Tomic-Canic, Marjana.
In: Journal of Investigative Dermatology, Vol. 136, No. 10, 01.10.2016, p. 1938-1941.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth
AU - Stojadinovic, Olivera
AU - Lindley, Linsey E.
AU - Jozic, Ivan
AU - Tomic-Canic, Marjana
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor. In light of this, one can speculate that some of the GC-mediated side effects can be remedied by blocking activation of the mineralocorticoid receptor. Indeed, according to Nguyen et al., local inhibition of the mineralocorticoid receptor via antagonists (spironolactone, canrenoate, and eplerenone) rescues GC-induced delayed epithelialization and accelerates wound closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte proliferation. These findings suggest that the use of mineralocorticoid receptor antagonists coupled with GC therapy may be beneficial in overcoming at least some of the GC-mediated side effects.
AB - Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor. In light of this, one can speculate that some of the GC-mediated side effects can be remedied by blocking activation of the mineralocorticoid receptor. Indeed, according to Nguyen et al., local inhibition of the mineralocorticoid receptor via antagonists (spironolactone, canrenoate, and eplerenone) rescues GC-induced delayed epithelialization and accelerates wound closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte proliferation. These findings suggest that the use of mineralocorticoid receptor antagonists coupled with GC therapy may be beneficial in overcoming at least some of the GC-mediated side effects.
UR - http://www.scopus.com/inward/record.url?scp=84996956048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84996956048&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2016.07.025
DO - 10.1016/j.jid.2016.07.025
M3 - Comment/debate
VL - 136
SP - 1938
EP - 1941
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 10
ER -