Mind the gap: The mismatch between clinical and imaging metrics in ALS

Esther Verstraete, Martin R. Turner, Julian Grosskreutz, Massimo Filippi, Michael G Benatar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.

Original languageEnglish (US)
Pages (from-to)524-529
Number of pages6
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume16
Issue number7-8
DOIs
StatePublished - Nov 27 2015

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Amyotrophic Lateral Sclerosis
Motor Neurons
Disease Progression
Biomarkers
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Mind the gap : The mismatch between clinical and imaging metrics in ALS. / Verstraete, Esther; Turner, Martin R.; Grosskreutz, Julian; Filippi, Massimo; Benatar, Michael G.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 16, No. 7-8, 27.11.2015, p. 524-529.

Research output: Contribution to journalArticle

Verstraete, Esther ; Turner, Martin R. ; Grosskreutz, Julian ; Filippi, Massimo ; Benatar, Michael G. / Mind the gap : The mismatch between clinical and imaging metrics in ALS. In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2015 ; Vol. 16, No. 7-8. pp. 524-529.
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