"Milwaukee shoulder" syndrome: Microspherules containing hydroxyapatite, active collagenase and neutral protease in patients with rotator cuff defects and glenohumeral osteoarthritis

Daniel J. McCarty, Herman S. Cheung, Paul B. Halverson, John C. Garancis

Research output: Contribution to journalArticle

6 Scopus citations


A new syndrome involving the shoulder joints is described, associating HA crystals in microspheroids, active collagenase, neutral protease with destruction of the fibrous rotator cuff and glenohumeral osteoarthritis. This pathogenetic mechanism postulated for this destructive arthropathy may have applicability for the devolutionary joint changes associated with other microcrystals found in joints and almost certainly applies to other joints besides the shoulder.

Original languageEnglish (US)
Pages (from-to)119-121
Number of pages3
JournalSeminars in Arthritis and Rheumatism
Issue number1 SUPPL. 1
StatePublished - 1981
Externally publishedYes


ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

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