'Milwaukee shoulder' - association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. II. Synovial fluid studies

P. B. Halverson, Herman S Cheung, D. J. McCarty, J. Garancis, N. Mandel

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Hydroxyapatite crystals in spheroid-shaped masses 1.9-15.6μ in diameter were found in 12 of 13 synovial fluids obtained from the shoulder joints of 4 patients with rotator cuff tears and glenohumeral osteoarthritis. Two of 16 control joint fluids also showed these particles. Collagen types I, II, and III were identified in the joint fluid pellets from 3 of the 4 patients, and fibers with typical collagen periodicity were also seen on transmission electronmicroscopy. Collagenase and neutral protease activities were found in fluids from 5 joints in 3 patients, whereas active collagenase was found in only 1 of 10 fluids from rheumatoid arthritis patients and in none of 3 fluids from patients with osteoarthritis. Neutral protease activities were present in several rheumatoid joint fluids. These findings are compatible with the hypothesis of an enzymatic release of hydroxyapatite crystals from the synovium and endocytosis by synovial macrophage-like cells with subsequent crystal-stimulated release of collagenase and neutral protease into the joint fluid, completing a pathogenetic cycle.

Original languageEnglish
Pages (from-to)474-483
Number of pages10
JournalArthritis and Rheumatism
Volume24
Issue number3
DOIs
StatePublished - Jun 29 1981
Externally publishedYes

Fingerprint

Rotator Cuff
Synovial Fluid
Collagenases
Durapatite
Peptide Hydrolases
Joints
Osteoarthritis
Shoulder Joint
Collagen Type III
Collagen Type II
Synovial Membrane
Periodicity
Collagen Type I
Endocytosis
Rheumatoid Arthritis
Collagen
Macrophages
Rotator Cuff Tear Arthropathy

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

'Milwaukee shoulder' - association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. II. Synovial fluid studies. / Halverson, P. B.; Cheung, Herman S; McCarty, D. J.; Garancis, J.; Mandel, N.

In: Arthritis and Rheumatism, Vol. 24, No. 3, 29.06.1981, p. 474-483.

Research output: Contribution to journalArticle

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