Military-related risk factors for dementia

Heather M. Snyder; Roxana O. Carare; Steven T. DeKosky; Mony J. de Leon; Derek Dykxhoorn; Li Gan; Raquel Gardner; Sidney R. Hinds; Michael Jaffee; Bruce T. Lamb; Susan Landau; Geoff Manley; Ann McKee; Daniel Perl; Julie A. Schneider; Michael Weiner; Cheryl Wellington; Kristine Yaffe; Lisa Bain; Anthony M. Pacifico; Maria C. Carrillo

doi:10.1016/j.jalz.2018.08.011

Military-related risk factors for dementia

Heather M. Snyder, Roxana O. Carare, Steven T. DeKosky, Mony J. de Leon, Derek Dykxhoorn, Li Gan, Raquel Gardner, Sidney R. Hinds, Michael Jaffee, Bruce T. Lamb, Susan Landau, Geoff Manley, Ann McKee, Daniel Perl, Julie A. Schneider, Michael Weiner, Cheryl Wellington, Kristine Yaffe, Lisa Bain, Anthony M. PacificoMaria C. Carrillo

Hussman Institute for Human Genomics

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Introduction: In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans. Methods: Building on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016. Results: During this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia. Discussion: The following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.

Original language	English (US)
Pages (from-to)	1651-1662
Number of pages	12
Journal	Alzheimer's and Dementia
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.jalz.2018.08.011
State	Published - Dec 2018

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2018.08.011

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Snyder, H. M., Carare, R. O., DeKosky, S. T., de Leon, M. J., Dykxhoorn, D., Gan, L., Gardner, R., Hinds, S. R., Jaffee, M., Lamb, B. T., Landau, S., Manley, G., McKee, A., Perl, D., Schneider, J. A., Weiner, M., Wellington, C., Yaffe, K., Bain, L., ... Carrillo, M. C. (2018). Military-related risk factors for dementia. Alzheimer's and Dementia, 14(12), 1651-1662. https://doi.org/10.1016/j.jalz.2018.08.011

Military-related risk factors for dementia. / Snyder, Heather M.; Carare, Roxana O.; DeKosky, Steven T.; de Leon, Mony J.; Dykxhoorn, Derek; Gan, Li; Gardner, Raquel; Hinds, Sidney R.; Jaffee, Michael; Lamb, Bruce T.; Landau, Susan; Manley, Geoff; McKee, Ann; Perl, Daniel; Schneider, Julie A.; Weiner, Michael; Wellington, Cheryl; Yaffe, Kristine; Bain, Lisa; Pacifico, Anthony M.; Carrillo, Maria C.

In: Alzheimer's and Dementia, Vol. 14, No. 12, 12.2018, p. 1651-1662.

Research output: Contribution to journal › Review article › peer-review

Snyder, HM, Carare, RO, DeKosky, ST, de Leon, MJ, Dykxhoorn, D, Gan, L, Gardner, R, Hinds, SR, Jaffee, M, Lamb, BT, Landau, S, Manley, G, McKee, A, Perl, D, Schneider, JA, Weiner, M, Wellington, C, Yaffe, K, Bain, L, Pacifico, AM & Carrillo, MC 2018, 'Military-related risk factors for dementia', Alzheimer's and Dementia, vol. 14, no. 12, pp. 1651-1662. https://doi.org/10.1016/j.jalz.2018.08.011

Snyder, Heather M. ; Carare, Roxana O. ; DeKosky, Steven T. ; de Leon, Mony J. ; Dykxhoorn, Derek ; Gan, Li ; Gardner, Raquel ; Hinds, Sidney R. ; Jaffee, Michael ; Lamb, Bruce T. ; Landau, Susan ; Manley, Geoff ; McKee, Ann ; Perl, Daniel ; Schneider, Julie A. ; Weiner, Michael ; Wellington, Cheryl ; Yaffe, Kristine ; Bain, Lisa ; Pacifico, Anthony M. ; Carrillo, Maria C. / Military-related risk factors for dementia. In: Alzheimer's and Dementia. 2018 ; Vol. 14, No. 12. pp. 1651-1662.

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abstract = "Introduction: In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans. Methods: Building on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016. Results: During this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia. Discussion: The following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.",

author = "Snyder, {Heather M.} and Carare, {Roxana O.} and DeKosky, {Steven T.} and {de Leon}, {Mony J.} and Derek Dykxhoorn and Li Gan and Raquel Gardner and Hinds, {Sidney R.} and Michael Jaffee and Lamb, {Bruce T.} and Susan Landau and Geoff Manley and Ann McKee and Daniel Perl and Schneider, {Julie A.} and Michael Weiner and Cheryl Wellington and Kristine Yaffe and Lisa Bain and Pacifico, {Anthony M.} and Carrillo, {Maria C.}",

note = "Funding Information: This meeting was organized and funded by the Alzheimer's Association . Investigators presented work funded by numerous funding sources, including National Institutes of Health and the U.S. Department of Defense . Thank you to all the study participants in the studies discussed throughout this manuscript. Publisher Copyright: {\textcopyright} 2018 The Authors",

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AU - Snyder, Heather M.

AU - Carare, Roxana O.

AU - DeKosky, Steven T.

AU - de Leon, Mony J.

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AU - Gan, Li

AU - Gardner, Raquel

AU - Hinds, Sidney R.

AU - Jaffee, Michael

AU - Lamb, Bruce T.

AU - Landau, Susan

AU - Manley, Geoff

AU - McKee, Ann

AU - Perl, Daniel

AU - Schneider, Julie A.

AU - Weiner, Michael

AU - Wellington, Cheryl

AU - Yaffe, Kristine

AU - Bain, Lisa

AU - Pacifico, Anthony M.

AU - Carrillo, Maria C.

N1 - Funding Information: This meeting was organized and funded by the Alzheimer's Association . Investigators presented work funded by numerous funding sources, including National Institutes of Health and the U.S. Department of Defense . Thank you to all the study participants in the studies discussed throughout this manuscript. Publisher Copyright: © 2018 The Authors

PY - 2018/12

Y1 - 2018/12

N2 - Introduction: In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans. Methods: Building on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016. Results: During this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia. Discussion: The following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.

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Military-related risk factors for dementia

Abstract

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