Mild Cognitive Impairment

Ranjan Duara, David A. Loewenstein, Clinton B Wright, Elizabeth Crocco, Daniel Varon

Research output: Chapter in Book/Report/Conference proceedingChapter


The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.

Original languageEnglish (US)
Title of host publicationDementia
Number of pages19
ISBN (Electronic)9781118656082
ISBN (Print)9780470674246
StatePublished - Oct 28 2013


  • Alzheimer's disease
  • Dementia
  • MCI
  • Mild cognitive impairment
  • Prodromal forms

ASJC Scopus subject areas

  • Medicine(all)


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