Mild Cognitive Impairment

Ranjan Duara, David Loewenstein, Clinton B Wright, Elizabeth Crocco, Daniel Varon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.

Original languageEnglish (US)
Title of host publicationDementia
PublisherWiley Blackwell
Pages77-95
Number of pages19
ISBN (Electronic)9781118656082
ISBN (Print)9780470674246
DOIs
StatePublished - Oct 28 2013

Fingerprint

Dementia
Alzheimer Disease
Cognitive Reserve
Medical Genetics
Biomarkers
Morbidity
Cognitive Dysfunction
Therapeutics
Recognition (Psychology)

Keywords

  • Alzheimer's disease
  • Dementia
  • MCI
  • Mild cognitive impairment
  • Prodromal forms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duara, R., Loewenstein, D., Wright, C. B., Crocco, E., & Varon, D. (2013). Mild Cognitive Impairment. In Dementia (pp. 77-95). Wiley Blackwell. https://doi.org/10.1002/9781118656082.ch6

Mild Cognitive Impairment. / Duara, Ranjan; Loewenstein, David; Wright, Clinton B; Crocco, Elizabeth; Varon, Daniel.

Dementia. Wiley Blackwell, 2013. p. 77-95.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duara, R, Loewenstein, D, Wright, CB, Crocco, E & Varon, D 2013, Mild Cognitive Impairment. in Dementia. Wiley Blackwell, pp. 77-95. https://doi.org/10.1002/9781118656082.ch6
Duara R, Loewenstein D, Wright CB, Crocco E, Varon D. Mild Cognitive Impairment. In Dementia. Wiley Blackwell. 2013. p. 77-95 https://doi.org/10.1002/9781118656082.ch6
Duara, Ranjan ; Loewenstein, David ; Wright, Clinton B ; Crocco, Elizabeth ; Varon, Daniel. / Mild Cognitive Impairment. Dementia. Wiley Blackwell, 2013. pp. 77-95
@inbook{9a96a55506494937ba93f34047aa7653,
title = "Mild Cognitive Impairment",
abstract = "The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.",
keywords = "Alzheimer's disease, Dementia, MCI, Mild cognitive impairment, Prodromal forms",
author = "Ranjan Duara and David Loewenstein and Wright, {Clinton B} and Elizabeth Crocco and Daniel Varon",
year = "2013",
month = "10",
day = "28",
doi = "10.1002/9781118656082.ch6",
language = "English (US)",
isbn = "9780470674246",
pages = "77--95",
booktitle = "Dementia",
publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - Mild Cognitive Impairment

AU - Duara, Ranjan

AU - Loewenstein, David

AU - Wright, Clinton B

AU - Crocco, Elizabeth

AU - Varon, Daniel

PY - 2013/10/28

Y1 - 2013/10/28

N2 - The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.

AB - The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.

KW - Alzheimer's disease

KW - Dementia

KW - MCI

KW - Mild cognitive impairment

KW - Prodromal forms

UR - http://www.scopus.com/inward/record.url?scp=85027989135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027989135&partnerID=8YFLogxK

U2 - 10.1002/9781118656082.ch6

DO - 10.1002/9781118656082.ch6

M3 - Chapter

SN - 9780470674246

SP - 77

EP - 95

BT - Dementia

PB - Wiley Blackwell

ER -