Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance

Gil Yosipovitch, Baruch Mevorah, Michael David, Maora Feinmesser, Emmilia Hodak, Boaz Gabay, Jamal Ammash, Peter M. Elias

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus. Observations: The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans- like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed. Conclusions: We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.

Original languageEnglish (US)
Pages (from-to)1237-1242
Number of pages6
JournalArchives of Dermatology
Volume135
Issue number10
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

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Ichthyosis
Skin Diseases
Type 2 Diabetes Mellitus
Insulin Resistance
Acanthosis Nigricans
Consanguinity

ASJC Scopus subject areas

  • Dermatology

Cite this

Yosipovitch, G., Mevorah, B., David, M., Feinmesser, M., Hodak, E., Gabay, B., ... Elias, P. M. (1999). Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance. Archives of Dermatology, 135(10), 1237-1242. https://doi.org/10.1001/archderm.135.10.1237

Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance. / Yosipovitch, Gil; Mevorah, Baruch; David, Michael; Feinmesser, Maora; Hodak, Emmilia; Gabay, Boaz; Ammash, Jamal; Elias, Peter M.

In: Archives of Dermatology, Vol. 135, No. 10, 01.10.1999, p. 1237-1242.

Research output: Contribution to journalArticle

Yosipovitch, G, Mevorah, B, David, M, Feinmesser, M, Hodak, E, Gabay, B, Ammash, J & Elias, PM 1999, 'Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance', Archives of Dermatology, vol. 135, no. 10, pp. 1237-1242. https://doi.org/10.1001/archderm.135.10.1237
Yosipovitch, Gil ; Mevorah, Baruch ; David, Michael ; Feinmesser, Maora ; Hodak, Emmilia ; Gabay, Boaz ; Ammash, Jamal ; Elias, Peter M. / Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance. In: Archives of Dermatology. 1999 ; Vol. 135, No. 10. pp. 1237-1242.
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