Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance

Gil Yosipovitch, Baruch Mevorah, Michael David, Maora Feinmesser, Emmilia Hodak, Boaz Gabay, Jamal Ammash, Peter M. Elias

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus. Observations: The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans- like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed. Conclusions: We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.

Original languageEnglish (US)
Pages (from-to)1237-1242
Number of pages6
JournalArchives of dermatology
Volume135
Issue number10
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Yosipovitch, G., Mevorah, B., David, M., Feinmesser, M., Hodak, E., Gabay, B., Ammash, J., & Elias, P. M. (1999). Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance. Archives of dermatology, 135(10), 1237-1242. https://doi.org/10.1001/archderm.135.10.1237