Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course

Ilya Kister, A. B. Caminero, Teshamae S Monteith, A. Soliman, T. E. Bacon, J. H. Bacon, J. T. Kalina, M. Inglese, J. Herbert, R. B. Lipton

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The objectives of this study were: (1) to assess relative frequency of migraine in multiple sclerosis (MS) patients using the validated self-administered diagnostic questionnaire, and to compare the migraine rates in MS outpatients to age- and gender-matched historical population controls; (2) to compare clinical and radiographic characteristics in MS patients with migraine and headache-free MS patients. We conducted a cross-sectional study to assess the demographic profiles, headache features and clinical characteristics of MS patients attending a MS clinic using a questionnaire based on the American Migraine Prevalence and Prevention (AMPP) study. We compared the relative frequency of migraine in MS clinic patients and AMPP cohort. We also compared clinical and radiographic features in MS patients with migraine to an MS control group without headache. Among 204 MS patients, the relative frequency of migraine was threefold higher than in population controls both for women [55.7 vs. 17.1%; prevalence ratio (PR) = 3.26, p < 0.001] and men (18.4 vs. 5.6%; PR = 3.29, p < 0.001). In a series of logistic regression models that controlled for age, gender, disease duration, β-interferon use, and depression, migraine in MS patients was significantly associated (p < 0.01) with trigeminal and occipital neuralgia, facial pain, Lhermitte's sign, temporomandibular joint pain, non-headache pain and a past history of depression. Migraine status was not significantly associated with disability on patient-derived disability steps scale or T2 lesion burden on brain MRI. Migraine is three-times more common in MS clinic patients than in general population. MS-migraine group was more symptomatic than the MS-no headache group.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalJournal of Headache and Pain
Volume11
Issue number5
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Migraine Disorders
Multiple Sclerosis
Headache
Population Control
Cross-Sectional Studies
Logistic Models
Depression
Trigeminal Neuralgia
Facial Pain
Temporomandibular Joint
Arthralgia
Interferons
Outpatients
Demography

Keywords

  • Comorbidity
  • Cross-sectional study
  • Magnetic resonance imaging
  • Migraine
  • Multiple sclerosis
  • Symptomatology

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. / Kister, Ilya; Caminero, A. B.; Monteith, Teshamae S; Soliman, A.; Bacon, T. E.; Bacon, J. H.; Kalina, J. T.; Inglese, M.; Herbert, J.; Lipton, R. B.

In: Journal of Headache and Pain, Vol. 11, No. 5, 01.10.2010, p. 417-425.

Research output: Contribution to journalArticle

Kister, I, Caminero, AB, Monteith, TS, Soliman, A, Bacon, TE, Bacon, JH, Kalina, JT, Inglese, M, Herbert, J & Lipton, RB 2010, 'Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course', Journal of Headache and Pain, vol. 11, no. 5, pp. 417-425. https://doi.org/10.1007/s10194-010-0237-9
Kister, Ilya ; Caminero, A. B. ; Monteith, Teshamae S ; Soliman, A. ; Bacon, T. E. ; Bacon, J. H. ; Kalina, J. T. ; Inglese, M. ; Herbert, J. ; Lipton, R. B. / Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. In: Journal of Headache and Pain. 2010 ; Vol. 11, No. 5. pp. 417-425.
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AU - Caminero, A. B.

AU - Monteith, Teshamae S

AU - Soliman, A.

AU - Bacon, T. E.

AU - Bacon, J. H.

AU - Kalina, J. T.

AU - Inglese, M.

AU - Herbert, J.

AU - Lipton, R. B.

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KW - Magnetic resonance imaging

KW - Migraine

KW - Multiple sclerosis

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