Migraine and cryptogenic stroke

Gretchen E. Tietjen, Tatjana Rundek

Research output: Contribution to journalReview articlepeer-review


The connection of migraine and stroke was first recognized 40 years ago in a study of stroke in young women. 1 The study centered on the relationship of stroke and oral contraceptives, but uncovered an association of migraine with both ischemic and hemorrhagic stroke even in those not using the pill. Over the ensuing years, a growing number of epidemiologic, 2 imaging, 3 and genetic investigations 4 have supported this early observation of an independent migraine/stroke link. Overall, the epidemiologic data have been strongest for ischemic stroke in young women with migraine with aura, but the relationship is also evident for hemorrhagic stroke and migraine without aura, and is found in men and the elderly. Studies across the spectrum of age have shown the most robust migraine/stroke association in those without traditional cardiovascular risk factors. 5

Original languageEnglish (US)
Pages (from-to)1436-1437
Number of pages2
Issue number17
StatePublished - Oct 27 2015

ASJC Scopus subject areas

  • Clinical Neurology


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