MIF-I's differential actions as an opiate antagonist

Abba J. Kastin, Richard D. Olson, Rudolph H. Ehrensing, Matthew C. Berzas, Andrew V Schally, David H. Coy

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.

Original languageEnglish
Pages (from-to)721-723
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume11
Issue number6
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Opiate Alkaloids
MSH Release-Inhibiting Hormone
Naloxone
Vas Deferens
Enkephalins
Morphine
Analgesics
Tail
Rats
Assays
Eating

Keywords

  • Analgesia
  • Food intake
  • MIF-I
  • Opiate
  • Peptide
  • Receptor
  • Vas deferens

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Kastin, A. J., Olson, R. D., Ehrensing, R. H., Berzas, M. C., Schally, A. V., & Coy, D. H. (1979). MIF-I's differential actions as an opiate antagonist. Pharmacology, Biochemistry and Behavior, 11(6), 721-723. https://doi.org/10.1016/0091-3057(79)90270-3

MIF-I's differential actions as an opiate antagonist. / Kastin, Abba J.; Olson, Richard D.; Ehrensing, Rudolph H.; Berzas, Matthew C.; Schally, Andrew V; Coy, David H.

In: Pharmacology, Biochemistry and Behavior, Vol. 11, No. 6, 01.01.1979, p. 721-723.

Research output: Contribution to journalArticle

Kastin, AJ, Olson, RD, Ehrensing, RH, Berzas, MC, Schally, AV & Coy, DH 1979, 'MIF-I's differential actions as an opiate antagonist', Pharmacology, Biochemistry and Behavior, vol. 11, no. 6, pp. 721-723. https://doi.org/10.1016/0091-3057(79)90270-3
Kastin, Abba J. ; Olson, Richard D. ; Ehrensing, Rudolph H. ; Berzas, Matthew C. ; Schally, Andrew V ; Coy, David H. / MIF-I's differential actions as an opiate antagonist. In: Pharmacology, Biochemistry and Behavior. 1979 ; Vol. 11, No. 6. pp. 721-723.
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