MIF-I's differential actions as an opiate antagonist

Abba J. Kastin, Richard D. Olson, Rudolph H. Ehrensing, Matthew C. Berzas, Andrew V. Schally, David H. Coy

Research output: Contribution to journalArticle

111 Scopus citations


The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.

Original languageEnglish (US)
Pages (from-to)721-723
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Issue number6
StatePublished - Dec 1979
Externally publishedYes


  • Analgesia
  • Food intake
  • MIF-I
  • Opiate
  • Peptide
  • Receptor
  • Vas deferens

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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  • Cite this

    Kastin, A. J., Olson, R. D., Ehrensing, R. H., Berzas, M. C., Schally, A. V., & Coy, D. H. (1979). MIF-I's differential actions as an opiate antagonist. Pharmacology, Biochemistry and Behavior, 11(6), 721-723. https://doi.org/10.1016/0091-3057(79)90270-3