MIF-I's differential actions as an opiate antagonist

Abba J. Kastin, Richard D. Olson, Rudolph H. Ehrensing, Matthew C. Berzas, Andrew V. Schally, David H. Coy

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.

Original languageEnglish (US)
Pages (from-to)721-723
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume11
Issue number6
DOIs
StatePublished - Dec 1979
Externally publishedYes

Keywords

  • Analgesia
  • Food intake
  • MIF-I
  • Opiate
  • Peptide
  • Receptor
  • Vas deferens

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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