Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

Farida Hellal, Andres Hurtado, Jörg Ruschel, Kevin C. Flynn, Claudia J. Laskowski, Martina Umlauf, Lukas C. Kapitein, Dinara Strikis, Vance Lemmon, John Bixby, Casper C. Hoogenraad, Frank Bradke

Research output: Contribution to journalArticle

344 Scopus citations

Abstract

Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-β signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.

Original languageEnglish (US)
Pages (from-to)928-931
Number of pages4
JournalScience
Volume331
Issue number6019
DOIs
StatePublished - Feb 18 2011

ASJC Scopus subject areas

  • General

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    Hellal, F., Hurtado, A., Ruschel, J., Flynn, K. C., Laskowski, C. J., Umlauf, M., Kapitein, L. C., Strikis, D., Lemmon, V., Bixby, J., Hoogenraad, C. C., & Bradke, F. (2011). Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science, 331(6019), 928-931. https://doi.org/10.1126/science.1201148