The microtubule cytoskeleton has an important role in the control of mitochondrial distribution in higher eukaryotes. In humans, defects in axonal mitochondrial transport are linked to neurodegenerative diseases. This chapter highlights fission yeast Schizosaccharomyces pombe as a powerful genetic model system for the study of microtubule-dependent mitochondrial movement, dynamics and inheritance.
|Number of pages||19|
|State||Published - Aug 20 2010|
|Name||Methods in Cell Biology|
ASJC Scopus subject areas
- Cell Biology