Microstimulation of the dorsolateral prefrontal cortex biases saccade target selection

Ioan Opris, Andrei Barborica, Vincent P. Ferrera

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A long-standing issue concerning the executive function of the primate dorsolateral prefrontal cortex is how the activity of prefrontal neurons is linked to behavioral response selection. To establish a functional relationship between prefrontal memory fields and saccade target selection, we trained three macaque monkeys to make saccades to the remembered location of a visual cue in a delayed spatial match-to-sample saccade task. We electrically stimulated sites in the prefrontal cortex with subthreshold currents during the delay epoch while monkeys performed this task. Our results show that the artificially injected signal interacts with the neural activity responsible for target selection, biasing saccade choices either towards the receptive/movement field (KF/MF) or away from the RF/MF, depending on the stimulation site. These findings might reflect a functional link between prefrontal signals responsible for the selection bias by modulating the balance between excitation and inhibition in the competitive interactions underlying behavioral selection.

Original languageEnglish (US)
Pages (from-to)893-904
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Fingerprint

Saccades
Prefrontal Cortex
trend
Haplorhini
Selection Bias
Executive Function
Macaca
Primates
Cues
Neurons
interaction
Monkey

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience

Cite this

Microstimulation of the dorsolateral prefrontal cortex biases saccade target selection. / Opris, Ioan; Barborica, Andrei; Ferrera, Vincent P.

In: Journal of Cognitive Neuroscience, Vol. 17, No. 6, 01.06.2005, p. 893-904.

Research output: Contribution to journalArticle

Opris, Ioan ; Barborica, Andrei ; Ferrera, Vincent P. / Microstimulation of the dorsolateral prefrontal cortex biases saccade target selection. In: Journal of Cognitive Neuroscience. 2005 ; Vol. 17, No. 6. pp. 893-904.
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