Microscopic changes in the condyle and disc in response to distraction osteogenesis of the minipig mandible

Petra Thurmüller, Maria J. Troulis, Andrew Rosenberg, Sung Kiang Chuang, Leonard B. Kaban

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: Unilateral mandibular distraction osteogenesis (DO) has been shown to cause gross changes in the mandibular condyle and articular disc. The purpose of this study was to correlate histologic findings with these gross changes in a minipig distraction model. Materials and Methods: Semiburied distractors were placed via submandibular incisions in 15 minipigs. Two unoperated animals served as controls. The protocol consisted of 0-day latency and rates of 1, 2, or 4 mm/day for a 12-mm gap. After the minipigs were killed (at 0, 24, or 90 days), ipsilateral and contralateral condyles and discs were harvested, decalcified, prepared for standard paraffin embedding, and evaluated to determine changes in 1) morphology and thickness of the articular cartilage and subchondral bone and 2) morphology of the disc. Results: In control animals, there were no degenerative changes in the articular cartilage and underlying condylar bone; there were no significant differences in the mean articular cartilage thickness. The temporomandibular joint discs were normal. In experimental animals, distracted condyles showed increasing degenerative changes and mean articular cartilage thickness as the DO rate increased. The discs were thinner. These changes were present, but to a lesser degree, in the contralateral condyles. After 90 days, degenerative changes in the condyles and discs were reduced, after remodeling, except in the 4 mm/day DO group. Conclusions: Histologic changes in the condyles and temporomandibular joint discs in response to mandibular DO correlated with previously reported gross changes. These changes were greater at higher distraction rates and remodeling back to normal occurred in mandibular condyles distracted at 1 mm/day.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalJournal of Oral and Maxillofacial Surgery
Volume64
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Fingerprint

Distraction Osteogenesis
Miniature Swine
Mandible
Bone and Bones
Articular Cartilage
Temporomandibular Joint Disc
Mandibular Condyle
Paraffin Embedding
Joints

ASJC Scopus subject areas

  • Dentistry(all)
  • Surgery

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Microscopic changes in the condyle and disc in response to distraction osteogenesis of the minipig mandible. / Thurmüller, Petra; Troulis, Maria J.; Rosenberg, Andrew; Chuang, Sung Kiang; Kaban, Leonard B.

In: Journal of Oral and Maxillofacial Surgery, Vol. 64, No. 2, 01.02.2006, p. 249-258.

Research output: Contribution to journalArticle

Thurmüller, Petra ; Troulis, Maria J. ; Rosenberg, Andrew ; Chuang, Sung Kiang ; Kaban, Leonard B. / Microscopic changes in the condyle and disc in response to distraction osteogenesis of the minipig mandible. In: Journal of Oral and Maxillofacial Surgery. 2006 ; Vol. 64, No. 2. pp. 249-258.
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