Microsatellite instability is absent in liver and biliary mucosa of patients with primary sclerosing cholangitis

So Young Jin, Amy E. Noffsinger, Pablo Bejarano, Fredrick L. Weber, Douglas W. Hanto, Jenine M. Belli, Cecilia M. Fenoglio-Preiser

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Microsatellite instability occurs in the colonic mucosa of patients with inflammatory bowel disease and may predispose the mucosa to neoplastic transformation. It is unknown whether microsatellite instability also plays a role in the neoplastic risk associated with primary sclerosing cholangitis. We examined 134 tissue samples from 21 patients with sclerosing cholangitis for microsatellite instability at eight loci. All tissues were also stained immunohistochemically using an antibody to the proliferation marker Ki-67. Microsatellite instability did not occur in any samples from the intrahepatic or extrahepatic biliary system, although one patient demonstrated instability in the colon. Ki-67 indices ranged from 0 to 2.5 in nondysplastic biliary epithelium and from 1.5 to 29.4 in areas of dysplasia. The absence of microsatellite instability in sclerosing cholangitis suggests that the genetic basis of neoplastic progression in chronic inflammatory disease of the bile ducts differs from that of intestinal cancers arising in the setting of chronic inflammatory bowel disease and may relate to differences in the microenvironment in these two sites.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalDigestive Diseases and Sciences
Volume44
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Bile ducts
  • Cholangiocarcinoma
  • Inflammatory bowel disease
  • Replication error phenotype

ASJC Scopus subject areas

  • Gastroenterology

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    Jin, S. Y., Noffsinger, A. E., Bejarano, P., Weber, F. L., Hanto, D. W., Belli, J. M., & Fenoglio-Preiser, C. M. (1999). Microsatellite instability is absent in liver and biliary mucosa of patients with primary sclerosing cholangitis. Digestive Diseases and Sciences, 44(3), 595-601. https://doi.org/10.1023/A:1026621827208