MicroRNAs in Pancreas and Islet Development

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.

Original languageEnglish (US)
Title of host publicationMicroRNA in Regenerative Medicine
PublisherElsevier Inc.
Pages401-418
Number of pages18
ISBN (Print)9780124058583, 9780124055445
DOIs
StatePublished - Dec 23 2014

Fingerprint

MicroRNAs
Pancreas
Cell Physiological Phenomena
Cell Transplantation
Gene Expression Regulation
Human Development
Islets of Langerhans
Health
Therapeutics
Genes

Keywords

  • Diabetes
  • Differentiation
  • Insulin
  • Islet development
  • Islets
  • MicroRNAs
  • MiRNAs
  • Noncoding RNAs
  • Pancreas
  • Pancreas development
  • β cells

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Dominguez-Bendala, J., Klein, D., & Pastori, R. (2014). MicroRNAs in Pancreas and Islet Development. In MicroRNA in Regenerative Medicine (pp. 401-418). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405544-5.00016-2

MicroRNAs in Pancreas and Islet Development. / Dominguez-Bendala, Juan; Klein, Dagmar; Pastori, Ricardo.

MicroRNA in Regenerative Medicine. Elsevier Inc., 2014. p. 401-418.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dominguez-Bendala, J, Klein, D & Pastori, R 2014, MicroRNAs in Pancreas and Islet Development. in MicroRNA in Regenerative Medicine. Elsevier Inc., pp. 401-418. https://doi.org/10.1016/B978-0-12-405544-5.00016-2
Dominguez-Bendala J, Klein D, Pastori R. MicroRNAs in Pancreas and Islet Development. In MicroRNA in Regenerative Medicine. Elsevier Inc. 2014. p. 401-418 https://doi.org/10.1016/B978-0-12-405544-5.00016-2
Dominguez-Bendala, Juan ; Klein, Dagmar ; Pastori, Ricardo. / MicroRNAs in Pancreas and Islet Development. MicroRNA in Regenerative Medicine. Elsevier Inc., 2014. pp. 401-418
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