Abstract
MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.
| Original language | English (US) |
|---|---|
| Title of host publication | MicroRNA in Regenerative Medicine |
| Publisher | Elsevier Inc. |
| Pages | 401-418 |
| Number of pages | 18 |
| ISBN (Print) | 9780124058583, 9780124055445 |
| DOIs | |
| State | Published - Dec 23 2014 |
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Keywords
- Diabetes
- Differentiation
- Insulin
- Islet development
- Islets
- MicroRNAs
- MiRNAs
- Noncoding RNAs
- Pancreas
- Pancreas development
- β cells
ASJC Scopus subject areas
- Immunology and Microbiology(all)
Cite this
MicroRNAs in Pancreas and Islet Development. / Dominguez-Bendala, Juan; Klein, Dagmar; Pastori, Ricardo.
MicroRNA in Regenerative Medicine. Elsevier Inc., 2014. p. 401-418.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - MicroRNAs in Pancreas and Islet Development
AU - Dominguez-Bendala, Juan
AU - Klein, Dagmar
AU - Pastori, Ricardo
PY - 2014/12/23
Y1 - 2014/12/23
N2 - MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.
AB - MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.
KW - Diabetes
KW - Differentiation
KW - Insulin
KW - Islet development
KW - Islets
KW - MicroRNAs
KW - MiRNAs
KW - Noncoding RNAs
KW - Pancreas
KW - Pancreas development
KW - β cells
UR - http://www.scopus.com/inward/record.url?scp=84943273854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943273854&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-405544-5.00016-2
DO - 10.1016/B978-0-12-405544-5.00016-2
M3 - Chapter
SN - 9780124058583
SN - 9780124055445
SP - 401
EP - 418
BT - MicroRNA in Regenerative Medicine
PB - Elsevier Inc.
ER -