MicroRNAs in Pancreas and Islet Development

Juan Domínguez-Bendala; Dagmar Klein; Ricardo L. Pastori

doi:10.1016/B978-0-12-405544-5.00016-2

MicroRNAs in Pancreas and Islet Development

Juan Domínguez-Bendala, Dagmar Klein, Ricardo L. Pastori

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.

Original language	English (US)
Title of host publication	MicroRNA in Regenerative Medicine
Publisher	Elsevier Inc.
Pages	401-418
Number of pages	18
ISBN (Electronic)	9780124058583
ISBN (Print)	9780124055445
DOIs	https://doi.org/10.1016/B978-0-12-405544-5.00016-2
State	Published - Jan 1 2015

Keywords

Diabetes
Differentiation
Insulin
Islet development
Islets
MiRNAs
MicroRNAs
Noncoding RNAs
Pancreas
Pancreas development
β cells

ASJC Scopus subject areas

Immunology and Microbiology(all)

Access to Document

10.1016/B978-0-12-405544-5.00016-2

Fingerprint Dive into the research topics of 'MicroRNAs in Pancreas and Islet Development'. Together they form a unique fingerprint.

Cite this

@inbook{cd3e984ee98c44c39b254b3bffd1b2f5,

title = "MicroRNAs in Pancreas and Islet Development",

abstract = "MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.",

keywords = "Diabetes, Differentiation, Insulin, Islet development, Islets, MiRNAs, MicroRNAs, Noncoding RNAs, Pancreas, Pancreas development, β cells",

author = "Juan Dom{\'i}nguez-Bendala and Dagmar Klein and Pastori, {Ricardo L.}",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-405544-5.00016-2",

language = "English (US)",

isbn = "9780124055445",

pages = "401--418",

booktitle = "MicroRNA in Regenerative Medicine",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - MicroRNAs in Pancreas and Islet Development

AU - Domínguez-Bendala, Juan

AU - Klein, Dagmar

AU - Pastori, Ricardo L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.

AB - MicroRNAs (miRNAs) control pancreatic and islet development, as well as β cell physiology. For this reason they have an important role in the regulation of gene expression in health and in disease, including diabetes. Each phase of human pancreatic development exhibits a specific miRNA profile. The expression of multiple miRNAs is inversely correlated with the expression of involved critical genes, suggesting miRNA-mediated regulation. Modulation of miRNAs to restore β cells is a potential strategy in diabetes treatment. However, current therapeutic approaches based on manipulation of miRNA expression are more feasible in vitro than in vivo because of difficulties with specific delivery. This chapter discusses the miRNAs involved in islet and pancreas development in the context of diabetes. It also looks at their potential role in the generation of surrogate β cells for transplantation.

KW - Diabetes

KW - Differentiation

KW - Insulin

KW - Islet development

KW - Islets

KW - MiRNAs

KW - MicroRNAs

KW - Noncoding RNAs

KW - Pancreas

KW - Pancreas development

KW - β cells

UR - http://www.scopus.com/inward/record.url?scp=84943273854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943273854&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-405544-5.00016-2

DO - 10.1016/B978-0-12-405544-5.00016-2

M3 - Chapter

AN - SCOPUS:84943273854

SN - 9780124055445

SP - 401

EP - 418

BT - MicroRNA in Regenerative Medicine

PB - Elsevier Inc.

ER -