MicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP

Alvaro J. Alencar, Raquel Malumbres, Goldi A. Kozloski, Ranjana Advani, Neha Talreja, Shideh Chinichian, Javier Briones, Yasodha Natkunam, Laurie H. Sehn, Randy D. Gascoyne, Rob Tibshirani, Izidore Lossos

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Purpose: Diffuse large B-cell lymphoma (DLBCL) heterogeneity has prompted investigations for new biomarkers that can accurately predict survival. A previously reported 6-gene model combined with the International Prognostic Index (IPI) could predict patients' outcome. However, even these predictors are not capable of unambiguously identifying outcome, suggesting that additional biomarkers might improve their predictive power. Experimental Design: We studied expression of 11 microRNAs (miRNA) that had previously been reported to have variable expression in DLBCL tumors. We measured the expression of each miRNA by quantitative real-time PCR analyses in 176 samples from uniformly treated DLBCL patients and correlated the results to survival. Results: In a univariate analysis, the expression of miR-18a correlated with overall survival (OS), whereas the expression of miR-181a and miR-222 correlated with progression-free survival (PFS). A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS. Conclusion: The expression of specific miRNAs may be useful for DLBCL survival prediction and their role in the pathogenesis of this disease should be examined further.

Original languageEnglish
Pages (from-to)4125-4135
Number of pages11
JournalClinical Cancer Research
Volume17
Issue number12
DOIs
StatePublished - Jun 15 2011

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Lymphoma, Large B-Cell, Diffuse
MicroRNAs
Survival
Disease-Free Survival
Biomarkers
Genes
Real-Time Polymerase Chain Reaction
Cell Survival
B-Lymphocytes
Research Design
Regression Analysis
Mortality
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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MicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP. / Alencar, Alvaro J.; Malumbres, Raquel; Kozloski, Goldi A.; Advani, Ranjana; Talreja, Neha; Chinichian, Shideh; Briones, Javier; Natkunam, Yasodha; Sehn, Laurie H.; Gascoyne, Randy D.; Tibshirani, Rob; Lossos, Izidore.

In: Clinical Cancer Research, Vol. 17, No. 12, 15.06.2011, p. 4125-4135.

Research output: Contribution to journalArticle

Alencar, AJ, Malumbres, R, Kozloski, GA, Advani, R, Talreja, N, Chinichian, S, Briones, J, Natkunam, Y, Sehn, LH, Gascoyne, RD, Tibshirani, R & Lossos, I 2011, 'MicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP', Clinical Cancer Research, vol. 17, no. 12, pp. 4125-4135. https://doi.org/10.1158/1078-0432.CCR-11-0224
Alencar, Alvaro J. ; Malumbres, Raquel ; Kozloski, Goldi A. ; Advani, Ranjana ; Talreja, Neha ; Chinichian, Shideh ; Briones, Javier ; Natkunam, Yasodha ; Sehn, Laurie H. ; Gascoyne, Randy D. ; Tibshirani, Rob ; Lossos, Izidore. / MicroRNAs are independent predictors of outcome in diffuse large B-cell lymphoma patients treated with R-CHOP. In: Clinical Cancer Research. 2011 ; Vol. 17, No. 12. pp. 4125-4135.
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