MicroRNAs and metastasis

Little RNAs go a long way

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

MicroRNAs (miRNA) are key regulators of many important biological processes from insulin secretion and fat metabolism to cellular proliferation and differentiation. Given the critical role that these small regulatory RNAs play in biology, it is not surprising that the alteration of miRNA expression patterns can have pathogenic consequences. The association between miRNA dysregulation and pathogenesis has been most widely studied in tumorigenesis, and a large number of miRNAs have been identified whose expression levels are changed in various tumor types. Although the role that miRNAs play in the development of metastasis is more poorly defined, recent studies have begun to identify miRNAs that can regulate key steps in the metastatic cascade. This review focuses on two emerging stories, the regulation of the epithelial-to-mesenchymal transition by members of the miR-200 family, and the pleiotropic nature of the metastasis suppressor miR-31.

Original languageEnglish
Pages (from-to)6401-6406
Number of pages6
JournalCancer Research
Volume70
Issue number16
DOIs
StatePublished - Aug 15 2010

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MicroRNAs
RNA
Neoplasm Metastasis
Biological Phenomena
Epithelial-Mesenchymal Transition
Carcinogenesis
Fats
Cell Proliferation
Insulin
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

MicroRNAs and metastasis : Little RNAs go a long way. / Dykxhoorn, Derek M.

In: Cancer Research, Vol. 70, No. 16, 15.08.2010, p. 6401-6406.

Research output: Contribution to journalArticle

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