MicroRNAs: A new piece in the paediatric cardiovascular disease puzzle

Ahmed Omran, Dalia Elimam, Keith A. Webster, Lina A. Shehadeh, Fei Yin

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Cardiovascular diseases in children comprise a large public health problem. The major goals of paediatric cardiologists and paediatric cardiovascular researchers are to identify the cause(s) of these diseases to improve treatment and preventive protocols. Recent studies show the involvement of microRNAs (miRs) in different aspects of heart development, function, and disease. Therefore, miR-based research in paediatric cardiovascular disorders is crucial for a better understanding of the underlying pathogenesis of the disease, and unravelling novel, efficient, preventive, and therapeutic means. The ultimate goal of such research is to secure normal cardiac development and hence decrease disabilities, improve clinical outcomes, and decrease the morbidity and mortality among children. This review focuses on the role of miRs in different paediatric cardiovascular conditions in an effort to encourage miR-based research in paediatric cardiovascular disorders.

Original languageEnglish (US)
Pages (from-to)642-655
Number of pages14
JournalCardiology in the young
Volume23
Issue number5
DOIs
StatePublished - Oct 2013

Keywords

  • biomarker
  • cardiac stem cells
  • MicroRNAs
  • paediatric cardiovascular diseases
  • therapeutic target

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

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