MicroRNA dysregulation in psychiatric disease

Brooke H. Miller, Claes Wahlestedt

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

MicroRNAs (miRNAs) are small regulatory RNAs that individually regulate up to several hundred genes, and collectively may regulate as much as two-thirds of the transcriptome. Recent evidence supports a role for miRNA dysregulation in psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and autism. Small changes in miRNA expression can fine-tune the expression of multiple genes within a biological network, suggesting that miRNA dysregulation may underlie many of the molecular changes observed in psychiatric disease, and that therapeutic regulation of miRNA levels may represent a novel treatment option.

Original languageEnglish (US)
Pages (from-to)89-99
Number of pages11
JournalBrain research
Volume1338
DOIs
StatePublished - Jun 18 2010
Externally publishedYes

Keywords

  • Bipolar disorder
  • MicroRNA
  • miR-132
  • NMDA
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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