MicroRNA biogenesis and cancer

Richard I. Gregory, Ramin Shiekhattar

Research output: Contribution to journalReview article

506 Scopus citations

Abstract

MicroRNAs (miRNA) are a recently discovered family of short non-protein-coding RNAs that negatively regulate gene expression. Recent studies of miRNAs highlight a requirement for cell viability. Posttranscriptional silencing of target genes by miRNAs occurs either by targeting specific cleavage of homologous mRNAs, or by targeting specific inhibition of protein synthesis. We recently identified a multisubunit protein complex termed Microprocessor that is necessary and sufficient for processing miRNA precursor RNAs. Microprocessor contains Drosha, an RNase III endonuclease, and DGCR8, a gene deleted in DiGeorge syndrome. We consider recent findings that link miRNA perturbation to cancer.

Original languageEnglish (US)
Pages (from-to)3509-3512
Number of pages4
JournalCancer Research
Volume65
Issue number9
DOIs
StatePublished - May 1 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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